GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2797685 | 1 | rs697691 | chr1:7885354 | VAMP3 | chr1:7831329-7841491:+ | -0.19 | -3.36 | 0.000828 | Crohn's disease |
| THCA | cis | rs9638182 | 1 | rs6976930 | chr7:72885810 | MLXIPL | chr7:73007524-73038870:- | 0.21 | 3.93 | 9.92E-5 | Triglycerides |
| THCA | cis | rs6465657 | 1 | rs6977321 | chr7:97774859 | BHLHA15 | chr7:97840778-97842271:+ | -0.15 | -3.42 | 0.000677 | Prostate cancer (gene x gene interaction);Prostate cancer |
| THCA | cis | rs6465657 | 1 | rs6977321 | chr7:97774859 | BRI3 | chr7:97910979-97922275:+ | -0.11 | -4 | 7.25E-5 | Prostate cancer (gene x gene interaction);Prostate cancer |
| THCA | cis | rs6465657 | 1 | rs6977321 | chr7:97774859 | TECPR1 | chr7:97846060-97881468:- | -0.13 | -3.74 | 0.000204 | Prostate cancer (gene x gene interaction);Prostate cancer |
| THCA | cis | rs875971 | 1 | rs6979382 | chr7:65886375 | ASL | chr7:65540776-65558321:+ | -0.16 | -4.14 | 4.19E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6979382 | chr7:65886375 | GUSB | chr7:65425675-65447246:- | 0.26 | 4.98 | 8.85E-7 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6979382 | chr7:65886375 | LOC729156 | chr7:66274980-66309813:- | 0.16 | 3.44 | 0.00064 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6979382 | chr7:65886375 | RABGEF1 | chr7:66093890-66276446:+ | 0.66 | 14.26 | 1.04E-38 | Aortic root size |
| THCA | cis | rs41997 | 1 | rs6979663 | chr7:118050881 | ANKRD7 | chr7:117864712-117882782:+ | -0.27 | -4.47 | 9.57E-6 | Response to platinum-based chemotherapy in non-small-cell lung cancer |
| THCA | cis | rs875971 | 1 | rs697970 | chr7:65560052 | ASL | chr7:65540776-65558321:+ | 0.18 | 4.67 | 3.91E-6 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs697970 | chr7:65560052 | GUSB | chr7:65425675-65447246:- | -0.26 | -4.9 | 1.33E-6 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs697970 | chr7:65560052 | RABGEF1 | chr7:66093890-66276446:+ | -0.65 | -13.54 | 1.34E-35 | Aortic root size |
| THCA | cis | rs2129782 | 1 | rs6980734 | chr8:89446680 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs6472235 | 1 | rs6981354 | chr8:66865183 | PDE7A | chr8:66629906-66753755:- | -0.17 | -3.78 | 0.000178 | Myopia (pathological) |